منابع مشابه
Optimization of Combinatorial Mutagenesis
Protein engineering by combinatorial site-directed mutagenesis evaluates a portion of the sequence space near a target protein, seeking variants with improved properties (e.g., stability, activity, immunogenicity). In order to improve the hit-rate of beneficial variants in such mutagenesis libraries, we develop methods to select optimal positions and corresponding sets of the mutations that wil...
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Our ability to solve large, important combinatorial optimization problems has improved dramatically in the decade. The availability of reliable software, extremely fast and inexpensive hardware and high-level languages that make the modeling of complex problems much faster have led to a much greater demand for optimization tools. This paper highlights the major breakthroughs and then describes ...
متن کاملCombinatorial Optimization
Here we are given a finite connected undirected graph (V,E) (so V is the set of vertices and E the set of edges) and weights on the edges, i.e., c(e) ∈ R for all e ∈ E. The task is to find a set T ⊆ E such that (V, T ) is a (spanning) tree and ∑ e∈T c(e) is minimum. (Recall that a tree is a connected graph without cycles.) The figure below shows on the left a set V of eight points in the Euclid...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2011
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.2011.0152